Peptide Database

Peptide NameSLAY-screened peptide P1573

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC90H156N32O21S

DescriptionStandard

        YVPMPVSLRTRRRGRPI
    

Molecular Weight2054.47 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.55

Charge Density (pH 7.0) 0.2799

GRAVY Index-0.70

Hydrophobic Moment 0.42

Boman Index-0.38

Instability Index138.54

Aliphatic Index 80.00

Aromaticity 0.0588

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 872.74

LogP -7.90

H-bond Donors 33.0

H-bond Acceptors 27.0

Rotatable Bonds 63.0

Heavy Atoms 144.0

Ring Count 4.0

Amide Bonds 16.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0118760 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/