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MYP_088543
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Basic Information
RC-115
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
18 amino acids
C81H142N30O20S6
Standard
Sequence
GICRCICGRYICRCICGR
Physicochemical Analysis
2048.57 Da
8.98
3.70
3.41
0.2055
0.69
0.66
-0.06
0.54
86.67
0.0556
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
825.85
-8.70
38.0
30.0
67.0
137.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221643 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 98CN009 | JC53-BL cells
10 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0232509 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 93TH060 | JC53-BL cells
5 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0271403 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 92BR023 | JC53-BL cells
2.4 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0276127 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 92HT593 | JC53-BL cells
4.2 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0282158 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-16, 5-14, 7-12
Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 193317 | JC53-BL cells
7.1 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
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