Peptide Database

Peptide NameRC-115

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC81H142N30O20S6

DescriptionStandard

        GICRCICGRYICRCICGR
    

Molecular Weight2048.57 Da

Isoelectric Point (pI)8.98

Net Charge (pH 7.0)3.70

Net Charge (pH 7.4) 3.41

Charge Density (pH 7.0) 0.2055

GRAVY Index0.69

Hydrophobic Moment 0.66

Boman Index-0.06

Instability Index0.54

Aliphatic Index 86.67

Aromaticity 0.0556

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 825.85

LogP -8.70

H-bond Donors 38.0

H-bond Acceptors 30.0

Rotatable Bonds 67.0

Heavy Atoms 137.0

Ring Count 1.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0029110 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 5148-1382 | JC53-BL cells

Activity4.1 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0071210 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 HM14 | JC53-BL cells

Activity3.4 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0077011 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 92UG005 | JC53-BL cells

Activity4.1 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0106065 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 98TZ017 | JC53-BL cells

Activity7.1 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0120020 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyRetrocyclin

Tax ID32630.0

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Antiviral Anti-HIV Anti-HSV

TargetHIV-1, HSV-1, HSV-2

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