Peptide Database

Peptide NameresA signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme / Catalytic activity ▸ Protease ▸ Bacillus protease novo type (BPN') secretion

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC188H304N46O48S

DescriptionStandard

        MKKKRFYIRTGILLVLLAALGYTLYSAVFQNTESV
    

Molecular Weight4008.77 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)3.50

Net Charge (pH 7.4) 3.27

Charge Density (pH 7.0) 0.0999

GRAVY Index0.51

Hydrophobic Moment 0.42

Boman Index0.19

Instability Index32.72

Aliphatic Index 122.57

Aromaticity 0.1429

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1539.90

LogP -9.33

H-bond Donors 56.0

H-bond Acceptors 53.0

Rotatable Bonds 134.0

Heavy Atoms 283.0

Ring Count 5.0

Amide Bonds 36.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0079404 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus licheniformis DSM 13 = ATCC 14580 [Bacterium]

FamilySec signal peptide

Tax ID279010

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Bacillus protease novo type (BPN') secretion

TargetBacillus licheniformis △0F-3

Activity0.27 U/mL

MethodProtease activity assay

PaperDegering C, Eggert T, Puls M, et al. Optimization of Protease Secretion in Bacillus subtilis and Bacillus licheniformis by Screening of Homologous and Heterologous Signal Peptides[J]. Applied and Environmental Microbiology, 2010, 76(19): 6370-6376. PMID20709850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20709850/

RECORD: Rec_0116723 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus licheniformis DSM 13 = ATCC 14580 [Bacterium]

FamilySec signal peptide

Tax ID279010

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Bacillus protease novo type (BPN') secretion

TargetBacillus subtilis TEB1030

Activity0.34 U/mL

MethodProtease activity assay

PaperDegering C, Eggert T, Puls M, et al. Optimization of Protease Secretion in Bacillus subtilis and Bacillus licheniformis by Screening of Homologous and Heterologous Signal Peptides[J]. Applied and Environmental Microbiology, 2010, 76(19): 6370-6376. PMID20709850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20709850/

RECORD: Rec_0163262 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus licheniformis DSM 13 = ATCC 14580 [Bacterium]

FamilySec signal peptide

Tax ID279010

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Bacillus protease novo type (BPN') secretion

TargetBacillus licheniformis △0F-3

Activity0.22 U/mL

MethodProtease activity assay

PaperDegering C, Eggert T, Puls M, et al. Optimization of Protease Secretion in Bacillus subtilis and Bacillus licheniformis by Screening of Homologous and Heterologous Signal Peptides[J]. Applied and Environmental Microbiology, 2010, 76(19): 6370-6376. PMID20709850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20709850/