Peptide Database

Peptide NameDermaseptin-B2 (DRS-B2) (Adenoregulin) (Dermaseptin BII)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length81 amino acids

Chemical FormulaC386H630N102O128S3

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEMKRGLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAVGEQ
    

Molecular Weight8843.93 Da

Isoelectric Point (pI)4.70

Net Charge (pH 7.0)-6.47

Net Charge (pH 7.4) -6.75

Charge Density (pH 7.0) -0.0799

GRAVY Index-0.40

Hydrophobic Moment 0.68

Boman Index-0.05

Instability Index52.55

Aliphatic Index 85.68

Aromaticity 0.0494

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3756.25

LogP -35.28

H-bond Donors 128.0

H-bond Acceptors 125.0

Rotatable Bonds 319.0

Heavy Atoms 619.0

Ring Count 5.0

Amide Bonds 84.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0361029 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa bicolor [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Cytotoxic Hemolytic Synergistic peptide

TargetGram Negative Bacteria and Gram Positive Bacteria