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MYP_088492
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Basic Information
Ac-[Tyr8]H2-(8-15)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
8 amino acids
C38H59N9O13
Standard
Sequence
YGAVVNDL
Physicochemical Analysis
849.93 Da
4.05
-1.24
-1.44
-0.1550
0.66
0.38
0.36
-12.47
133.75
0.1250
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
367.64
-2.90
12.0
12.0
25.0
60.0
1.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0300175 VERIFIED: YES
Provenance & Taxonomy
Human alphaherpesvirus 1 [Virus]
Virus-derived peptide
10298;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 1 (Replication); BHK
21 μg
Ribonucleotide reductase assay
PaperSpecific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides. | Dutia BM, Frame MC, Subak-Sharpe JH, Clark WN, Marsden HS. | Nature. 1986 | PMID:3012359 PMID3012359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3012359/
RECORD: Rec_0309062 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral
Herpes simplex virus type 1
330 μM
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperStructure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase. | Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P. | J Biol Chem. 1987 Sep 15;262(26):12413-6. | DOI:Not available | PMID:3040743 PMID3040743 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3040743/
RECORD: Rec_0372481 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antiviral
Herpes simplex virus type 1
150 μM
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperStructure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase. | Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P. | J Biol Chem. 1987 Sep 15;262(26):12413-6. | DOI:Not available | PMID:3040743 PMID3040743 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3040743/
RECORD: Rec_0392386 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0424112 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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