Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2554H3983N657O734S18

DescriptionStandard

        MRTEQVPVLWAHFLLWNLCISSSQAVYPGIKARITQRALDYGVQVGMKMMEEMAKEIVIPDLKGSESLEFLKIDYVKYNFSNIKINAFSLPNTSLAFVPGVGIRALSNHGTANISANWEVRAPLFQDSGAADLFLSGIYFAGIIVLTRNDLGHPAVELQDCHAQVSHARVSFSGGLSVLYNSFAEPMEKPILRNLNEMLCPIVINEVDALNVNISALEVLTKIDNYTVLDCSLLSPPEVTENHLDLNLKGAFYPLESLVDPPFLPAPFELPQNRDSMLYIGVSEYFFKSASFAHYVSGALGIMLSTKEISNYFNQNTQGIGSVLSKIAEIYVLSQPFMLQIMATGPPVINLHPNNFSLEFPASVIMLTELQNSTIEPIVSMDFIASTSVGLAILGQKLICSLSLNRFRLSLPENSHRDVKVVRFENILSSILHFGVLPLANTKLQRGFPLPNPYNISFLNSDIEVLEGFLLISTDLAHETPSRQQPNLHSWGGLHLVDGPWREQPNH
    

Molecular Weight56213.07 Da

Isoelectric Point (pI)5.38

Net Charge (pH 7.0)-14.26

Net Charge (pH 7.4) -15.36

Charge Density (pH 7.0) -0.0281

GRAVY Index0.14

Hydrophobic Moment 0.73

Boman Index0.17

Instability Index36.99

Aliphatic Index 106.13

Aromaticity 0.0907

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393674 VERIFIED: NO

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyBPI/LBP

Tax ID10036

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria