Peptide Database

Peptide NameCathelicidin-related peptide Pt_CRAMP2 (Cathelicidin-related antimicrobial peptide) (CRAMP) (Vipericidin)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length184 amino acids

Chemical FormulaC952H1479N241O289S6

DescriptionStandard

        MDGFFWKTWLVVAALAIGGTSSLPHKPLTYEEAVDLAVSTYNGKSGEESLYRLLEAVPPPKWDPLSESNQELNLTIKETVCLVAEERSLEECDFQDDGAVMGCTGYFFFGESPPVLVLTCEPLGEDEEQNQEEEEEEEKEEDEKDQPRRVKRFKKFFRKLKKSVKKRVKKFFKKPRVIGVTIPF
    

Molecular Weight21116.76 Da

Isoelectric Point (pI)4.91

Net Charge (pH 7.0)-9.39

Net Charge (pH 7.4) -9.80

Charge Density (pH 7.0) -0.0510

GRAVY Index-0.59

Hydrophobic Moment 0.95

Boman Index-0.08

Instability Index58.17

Aliphatic Index 72.50

Aromaticity 0.1033

Extinction Coeff. Reduced 22460.00

Extinction Coeff. Oxidized 22710.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8544.67

LogP -89.92

H-bond Donors 292.0

H-bond Acceptors 287.0

Rotatable Bonds 702.0

Heavy Atoms 1488.0

Ring Count 35.0

Amide Bonds 192.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0336739 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudonaja textilis [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-positive Cytotoxic Hemolytic

TargetPichia pastoris

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