Peptide Database

Peptide NameCrustacean hyperglycemic hormone B

Function Ontology

Developmental biology ▸ Molting regulation

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC377H590N104O113S7

DescriptionStandard

        QVFDQACKGVYDRNLFKKLNRVCEDCYNLYRKPFIVTTCRENCYSNRVFRQCLDDLLLSDVIDEYVSNVQMV
    

Molecular Weight8611.80 Da

Isoelectric Point (pI)6.33

Net Charge (pH 7.0)-0.29

Net Charge (pH 7.4) -0.61

Charge Density (pH 7.0) -0.0041

GRAVY Index-0.30

Hydrophobic Moment 0.85

Boman Index-0.12

Instability Index18.59

Aliphatic Index 86.39

Aromaticity 0.1250

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3602.31

LogP -33.59

H-bond Donors 130.0

H-bond Acceptors 120.0

Rotatable Bonds 288.0

Heavy Atoms 601.0

Ring Count 10.0

Amide Bonds 81.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0057268 VERIFIED: NO

Provenance & Taxonomy

OrganismHomarus americanus [Animal]

FamilyArthropod CHH/MIH/GIH/VIH hormone

Tax ID6706

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Other ModsPhe3 D-phenylalanine, in form CHH-B-II

Bio-Activity Profile

Function

Neuropeptide Arthropod neurohormone

RECORD: Rec_0247345 VERIFIED: YES

Provenance & Taxonomy

OrganismHomarus americanus [Animal]

FamilyCrustacean hyperglycemic hormone

Tax ID6706

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

ChiralityD-residue-containing modified peptide [Mixed]

N-TermPyroglutamate

C-TermAmidation

Disulfide7-43; 23-39; 26-52

Other Mods3:D-phenylalanine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Molting regulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0342506 VERIFIED: YES

Provenance & Taxonomy

OrganismHomarus americanus [Animal]

FamilyCrustacean hyperglycemic hormone

Tax ID6706

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

ChiralityD-residue-containing modified peptide [Mixed]

N-TermPyroglutamate

C-TermAmidation

Disulfide7-43; 23-39; 26-52

Other Mods3:D-phenylalanine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Molting regulator

Targetthe sinus gland

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour