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MYP_088390
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Basic Information
Protein GPR15LG
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Anticancer ▸ Tumor suppressor
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
81 amino acids
C409H678N124O101S7
Standard
Sequence
MRLLVLSSLLCILLLCFSIFSTEGKRRPAKAWSGRRTRLCCHRVPSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV
Physicochemical Analysis
9172.98 Da
10.54
10.71
10.24
0.1322
0.01
0.52
-0.03
58.30
102.22
0.0494
11000.00
11375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3569.29
-30.63
133.0
122.0
296.0
641.0
17.0
83.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009865 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID28936214 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28936214/
RECORD: Rec_0026626 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Cytokine Tumor suppressor Anticancer Chemotactic Non-hemolytic
Actinomyces (Gram-positive)
PaperA Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15; A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia; C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes; GPR15L is an epithelial inflammation-derived pruritogen PMID12975309;15164054;25351403;25585381;28936214;28900043;29872130;35704588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12975309/
RECORD: Rec_0085281 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Cytokine Tumor suppressor Anticancer Chemotactic Non-hemolytic
Staphylococcus aureus (Gram-positive)
PaperA Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15; A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia; C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes; GPR15L is an epithelial inflammation-derived pruritogen PMID12975309;15164054;25351403;25585381;28936214;28900043;29872130;35704588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12975309/
RECORD: Rec_0172919 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID28936214 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28936214/
RECORD: Rec_0260134 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Cytokine Tumor suppressor Anticancer Chemotactic Non-hemolytic
Mycoplasma (Gram-negative)
PaperA Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15; A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia; C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes; GPR15L is an epithelial inflammation-derived pruritogen PMID12975309;15164054;25351403;25585381;28936214;28900043;29872130;35704588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12975309/
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