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MYP_088372
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Basic Information
Ixodidin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
65 amino acids
C287H471N109O85S10
Standard
Sequence
QRGSRGQRCGPGEVFNQCGSACPRVCGRPPAQACTLQCVSGCFCRRGYIRTQRGGCIPERQCHQR
Physicochemical Analysis
7129.14 Da
9.53
8.75
8.35
0.1347
-0.72
0.58
-0.28
53.32
36.00
0.0462
1490.00
2115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3175.14
-46.50
122.0
105.0
232.0
491.0
9.0
73.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0286326 VERIFIED: YES
Provenance & Taxonomy
Boophilus microplus [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
None
9-34, 18-42, 22-38, 26-62, 44-56
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus
120-240 μM
MIC
PMID16191451 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16191451/
RECORD: Rec_0318191 VERIFIED: YES
Provenance & Taxonomy
Boophilus microplus [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Its N-terminus is blocked by pyroglutamate. It contains 15% Cys and Gly, 16% Arg and 12% Gln. The tick live in cattle. Active against M. luteus (MIC 0.12-0.24 uM) and E. coli (20% inhibition at 1 uM). Updated 5/2019; 7/2021
Bio-Activity Profile
Antimicrobial
Micrococcus luteus
0.12-0.24 μM
MIC
PaperIxodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases.
RECORD: Rec_0339383 VERIFIED: YES
Provenance & Taxonomy
Boophilus microplus [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
None
9-34, 18-42, 22-38, 26-62, 44-56
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli (20% inhibition at 1mM)
PMID16191451 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16191451/
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