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MYP_088245
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Basic Information
Angiotensin I converting enzyme inhibitior 2
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
9 amino acids
C48H75N15O18
Standard
Sequence
RNDDLNYIQ
Physicochemical Analysis
1150.20 Da
4.21
-1.24
-1.44
-0.1376
-1.67
0.12
-0.45
22.60
86.67
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
582.12
-6.45
19.0
17.0
38.0
81.0
1.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0125497 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Angiotensin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
3.72 μM
IC50
RECORD: Rec_0206795 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
9031.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
3.72
PaperEckert E., Zambrowicz A., Pokora M., Setner B., D?browska A., Szo?tysik M., Szewczuk Z., Polanowski A., Trziszka T., Chrzanowska J.. Egg-yolk protein by-product as a source of ACE-inhibitory peptides obtained with using unconventional proteinase from Asian pumpkin (Cucurbita ficifolia). Journal of Proteomics 110, 107-116.
RECORD: Rec_0339879 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
Dipeptidyl peptidase IV
PaperZambrowicz A., Eckert E., Pokora M., Bobak ?., D?browska A., Szo?tysik M., Trziszka T., Chrzanowska J.. Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia). RSC Adv. 5, 10460-10467.
RECORD: Rec_0368892 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperZambrowicz A., Eckert E., Pokora M., Bobak ?., D?browska A., Szo?tysik M., Trziszka T., Chrzanowska J.. Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia). RSC Adv. 5, 10460-10467.