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MYP_088220
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Basic Information
Esculentin-2CHa
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
37 amino acids
C173H289N47O47S2
Standard
Sequence
GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC
Physicochemical Analysis
3843.56 Da
9.79
4.74
4.49
0.1280
0.37
0.75
0.12
15.63
97.57
0.0811
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1527.55
-14.86
56.0
54.0
135.0
269.0
3.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0262686 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
RECORD: Rec_0291816 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
5 μM
MIC
RECORD: Rec_0303954 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Pseudomonas aeruginosa
5 μM
MIC
RECORD: Rec_0309415 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
5 μM
MIC
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
RECORD: Rec_0361829 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
150 μM
LC50
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
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