Peptide Database

Peptide NameIntermedin

Function Ontology

Cardiovascular

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC219H350N68O67S3

DescriptionStandard

        TQAQLLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSY
    

Molecular Weight5103.73 Da

Isoelectric Point (pI)7.80

Net Charge (pH 7.0)0.55

Net Charge (pH 7.4) 0.23

Charge Density (pH 7.0) 0.0118

GRAVY Index-0.32

Hydrophobic Moment 0.63

Boman Index0.00

Instability Index47.83

Aliphatic Index 80.85

Aromaticity 0.0426

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2163.68

LogP -26.64

H-bond Donors 75.0

H-bond Acceptors 73.0

Rotatable Bonds 161.0

Heavy Atoms 357.0

Ring Count 9.0

Amide Bonds 53.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0228399 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide10-15

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0376176 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyAdrenomedullin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Hormone Vasoregulatory peptide

RECORD: Rec_0397086 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

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