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MYP_088219
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Basic Information
Intermedin
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Standard
47 amino acids
C219H350N68O67S3
Standard
Sequence
TQAQLLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSY
Physicochemical Analysis
5103.73 Da
7.80
0.55
0.23
0.0118
-0.32
0.63
0.00
47.83
80.85
0.0426
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2163.68
-26.64
75.0
73.0
161.0
357.0
9.0
53.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023402 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Intermedin peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-aging Vasoprotective
Human VSMC CRL1999 cells (In vitro)
Western blot; Immunostaining; qRT-PCR
PaperIntermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1 PMID32229709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32229709/
RECORD: Rec_0041115 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Intermedin peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-aging Vasoprotective
Sprague-Dawley (SD) rats (In vivo)
Western blot; Immunostaining; qRT-PCR
PaperIntermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1 PMID32229709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32229709/
RECORD: Rec_0090231 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Intermedin peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-aging Vasoprotective
Rat vascular smooth muscle cells (VSMCs) (In vitro)
Western blot; Immunostaining; qRT-PCR
PaperIntermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1 PMID32229709 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32229709/
RECORD: Rec_0126024 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0203008 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Adrenomedullin
9606
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
Amidation
10-15
Bio-Activity Profile
Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Receptor modulation Feeding regulator
Mammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour
PMID10591208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10591208/
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