Peptide Database

Peptide NameEval418-FH4

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC83H116N24O16

DescriptionStandard

        LWHHIWNTVHHLI
    

Molecular Weight1705.96 Da

Isoelectric Point (pI)7.10

Net Charge (pH 7.0)0.11

Net Charge (pH 7.4) -0.30

Charge Density (pH 7.0) 0.0084

GRAVY Index0.15

Hydrophobic Moment 0.53

Boman Index0.40

Instability Index82.42

Aliphatic Index 142.31

Aromaticity 0.1538

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 622.14

LogP -0.38

H-bond Donors 22.0

H-bond Acceptors 20.0

Rotatable Bonds 49.0

Heavy Atoms 123.0

Ring Count 8.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0343136 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HSV Entry inhibition

TargetHSV-1 | Vero cells

Activity0.51 μM

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperHistidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z. | Theranostics. 2018 Jan 1;8(1):199-211. | DOI:10.7150/thno.21425 | PMID:29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/

RECORD: Rec_0344440 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Entry inhibition

Targetinhibition of viral attachment in Vero cells

Activity0.3693 μM

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperHistidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z. | Theranostics. 2018 Jan 1;8(1):199-211. | DOI:10.7150/thno.21425 | PMID:29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/

RECORD: Rec_0420990 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral

Targetinhibition of viral attachment in Vero cells

Activity0.63 μg/mL

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperHistidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z. | Theranostics. 2018 Jan 1;8(1):199-211. | DOI:10.7150/thno.21425 | PMID:29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/

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