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MYP_088190
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Basic Information
Eval418-FH4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C83H116N24O16
Standard
Sequence
LWHHIWNTVHHLI
Physicochemical Analysis
1705.96 Da
7.10
0.11
-0.30
0.0084
0.15
0.53
0.40
82.42
142.31
0.1538
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
622.14
-0.38
22.0
20.0
49.0
123.0
8.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008419 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0045831 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0059641 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of viral entry in Vero cells
4.37 μg/mL
IC50
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0066843 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of viral inactivation in Vero cells
0.87 μg/mL
IC50
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0089003 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
inhibition of viral entry in Vero cells
2.562 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperHistidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z. | Theranostics. 2018 Jan 1;8(1):199-211. | DOI:10.7150/thno.21425 | PMID:29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
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