‹ ›
MYP_088115
← PREVIOUS NEXT → BACK
Basic Information
C34
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
34 amino acids
C184H280N50O64S
Standard
Sequence
WMEWDREINNYTSLIHSLIEESQNQQEKNEQELL
Physicochemical Analysis
4248.55 Da
4.21
-6.13
-6.40
-0.1804
-1.27
0.58
-0.20
71.11
80.29
0.0882
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1916.07
-18.32
63.0
60.0
147.0
299.0
6.0
41.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0177795 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
HeLa
0.0073±0.0025 μM
IC50
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0181279 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 Bal | MT-2 cells
0.0076±0.0002 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0198670 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
MT-2
Qualitative inhibition
PaperDirect evidence that C-peptide inhibitors of human immunodeficiency virus type 1 entry bind to the gp41 N-helical domain in receptor-activated viral envelope. PMID12805467 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12805467/
RECORD: Rec_0240067 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
TZM-bl
0.01683 μM
IC50
PaperA multi-functional peptide as an HIV-1 entry inhibitor based on self-concentration PMID22760295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22760295/
RECORD: Rec_0242479 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G/N43D
PMID19114674;27795416;31805154;12203417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
FIRST PREV 1 2 3 4 5 6 NEXT LAST
Showing 5 records on this page · Page 3 of 6