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MYP_088115
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Basic Information
C34
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
34 amino acids
C184H280N50O64S
Standard
Sequence
WMEWDREINNYTSLIHSLIEESQNQQEKNEQELL
Physicochemical Analysis
4248.55 Da
4.21
-6.13
-6.40
-0.1804
-1.27
0.58
-0.20
71.11
80.29
0.0882
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1916.07
-18.32
63.0
60.0
147.0
299.0
6.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0122447 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
0.00068 μM
IC50
PaperRemodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells. PMID12203417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12203417/
RECORD: Rec_0127850 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G/V38A
PMID19114674;27795416;31805154;12203417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
RECORD: Rec_0128399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 IIIB | MT-2 cells
0.0072±0.0002 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0145683 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 JRCSF
PMID19114674;27795416;31805154;12203417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
RECORD: Rec_0169529 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 IIIB
PMID19114674;27795416;31805154;12203417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
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