Peptide Database

Peptide NameRibonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme / Catalytic activity ▸ Hydrolase ▸ Nuclease

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length156 amino acids

Chemical FormulaC767H1237N225O210S14

DescriptionStandard

        MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL
    

Molecular Weight17419.32 Da

Isoelectric Point (pI)9.76

Net Charge (pH 7.0)16.10

Net Charge (pH 7.4) 15.31

Charge Density (pH 7.0) 0.1032

GRAVY Index-0.42

Hydrophobic Moment 0.69

Boman Index-0.06

Instability Index52.89

Aliphatic Index 71.92

Aromaticity 0.0577

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6968.77

LogP -72.80

H-bond Donors 243.0

H-bond Acceptors 248.0

Rotatable Bonds 578.0

Heavy Atoms 1216.0

Ring Count 31.0

Amide Bonds 173.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0388801 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyPancreatic ribonuclease

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-positive Endonuclease Hydrolase Nuclease Non-hemolytic

TargetEnterococcus faecium (Gram-positive)