Peptide Database

Peptide NameBeta-defensin 43

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC364H598N106O94S9

DescriptionStandard

        MRVLFSILGVLTLLSIVPLARSFLENQDCSKHRHCRMKCKANEYAVRYCEDWTICCRVKKKESKKKKMW
    

Molecular Weight8251.88 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)9.62

Net Charge (pH 7.4) 9.19

Charge Density (pH 7.0) 0.1394

GRAVY Index-0.33

Hydrophobic Moment 0.56

Boman Index-0.17

Instability Index34.02

Aliphatic Index 81.88

Aromaticity 0.0870

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3289.01

LogP -26.08

H-bond Donors 125.0

H-bond Acceptors 115.0

Rotatable Bonds 286.0

Heavy Atoms 573.0

Ring Count 11.0

Amide Bonds 71.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0015689 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyDefensin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KM9/entry; https://bblserver.org.in/ampdb/