‹ ›
MYP_088020
← PREVIOUS NEXT → BACK
Basic Information
Nigrocin-2H
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
21 amino acids
C90H164N24O24S2
Standard
Sequence
GLLSKVLGVGKKVLCGVSGLC
Physicochemical Analysis
2030.54 Da
9.39
2.74
2.50
0.1303
1.21
0.53
0.37
-6.65
148.10
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
763.84
-6.66
29.0
29.0
71.0
140.0
0.0
20.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0379222 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial
S. dysenteriae, Klebsiella pneumoniae
10 μg/mL
MIC
PaperStructural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.
RECORD: Rec_0380137 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
15 μM
MIC
PaperStructural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.
RECORD: Rec_0381733 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0401343 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Nigrocin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae
10 μg/mL
MIC
PaperPubMed PMID: 11682065 PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
FIRST PREV 1 ... 6 7 8
Showing 4 records on this page · Page 8 of 8