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MYP_088020
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Basic Information
Nigrocin-2H
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
21 amino acids
C90H164N24O24S2
Standard
Sequence
GLLSKVLGVGKKVLCGVSGLC
Physicochemical Analysis
2030.54 Da
9.39
2.74
2.50
0.1303
1.21
0.53
0.37
-6.65
148.10
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
763.84
-6.66
29.0
29.0
71.0
140.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0339579 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial
Candida albicans
150 μg/mL
MIC
PaperStructural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata.
RECORD: Rec_0351652 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Nigrocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Serratia marcescens
PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
RECORD: Rec_0372565 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Nigrocin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
15-21
Bio-Activity Profile
Antimicrobial Antibacterial
PaperT. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis) Evidence URLhttps://www.uniprot.org/uniprotkb/B0B3Q2/entry
RECORD: Rec_0373297 VERIFIED: YES
Provenance & Taxonomy
Rana nigromaculata [Animal]
Nigrocin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
150 μg/mL
MIC
PaperPubMed PMID: 11682065 PMID11682065 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11682065/
RECORD: Rec_0377060 VERIFIED: NO
Provenance & Taxonomy
Amphibia [Animal]
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
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