Peptide Database

Peptide NameDefensin beta 136

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC399H615N105O99S10

DescriptionStandard

        MNLCLSSLLFFLVILLPSGKGMFGNDGVKVRTCTSQKAVCFFGCPPGYRWIAFCHNILSCCKNMTRFQPLQAKDPWVH
    

Molecular Weight8787.45 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)5.60

Net Charge (pH 7.4) 5.17

Charge Density (pH 7.0) 0.0718

GRAVY Index0.34

Hydrophobic Moment 0.60

Boman Index0.18

Instability Index57.49

Aliphatic Index 82.44

Aromaticity 0.1282

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3223.11

LogP -25.48

H-bond Donors 117.0

H-bond Acceptors 117.0

Rotatable Bonds 280.0

Heavy Atoms 613.0

Ring Count 19.0

Amide Bonds 84.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0097560 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Antifungal Fungicide Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetCandida albicans, Escherichia coli, Staphylococcus aureus

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KJ3/entry; https://bblserver.org.in/ampdb/