Peptide Database

Peptide NameSLAY-screened peptide P5173

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC84H120N20O28S2

DescriptionStandard

        YCATTYSDACSIFPHATA
    

Molecular Weight1922.10 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.17

Net Charge (pH 7.4) -1.46

Charge Density (pH 7.0) -0.0652

GRAVY Index0.27

Hydrophobic Moment 0.33

Boman Index0.25

Instability Index44.56

Aliphatic Index 43.89

Aromaticity 0.1667

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 756.82

LogP -9.16

H-bond Donors 29.0

H-bond Acceptors 30.0

Rotatable Bonds 53.0

Heavy Atoms 134.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0062406 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/