Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length504 amino acids

Chemical FormulaC2568H4046N696O727S15

DescriptionStandard

        MMARPYCVVVALLLLAMVSGFGEGASNPGFVARITRKGLEYGRRFGVAILKKELSTIKLPDFSGSFKVGWIKSVSYDFYRLKIHRFELRNSDLRLRPRQGVTASLSNNYVFVSGNWKVKKAFVTLDGTFDVSVDGISISVSLNLGKDHSGRPTASVAHCRSSIGHISADISGRLSWILNLFHERIENNFKNILEQKICEMVRKSTTSHLEPYLRTLPVILMIDQVAGIDYSLVGAPQVTSQVLDTPFKGEFFGRNWHSPAPFDAPTIRLTEKHDHMVYFAVSEYVFNTASRVYHQAGRMNFTIQNKHIPMDSPIRLHTSSFRTIIPRLARLNPNMELELETSPETAYLLEQWLARLYPNTELELEMSPESAPFLRFTPGNVTLMPVLDIQAFALLPTSSDRKPLFQLRVTTNISATISVSSDRIVGSVTTGSKLKLELKHSNVRFINVELMEAILNYYALHTIYPSLNAKLEEGFPLPLPRDTHLNSLELQVHENFLLLGANLD
    

Molecular Weight56782.80 Da

Isoelectric Point (pI)9.12

Net Charge (pH 7.0)7.93

Net Charge (pH 7.4) 6.75

Charge Density (pH 7.0) 0.0157

GRAVY Index-0.06

Hydrophobic Moment 0.83

Boman Index0.06

Instability Index33.11

Aliphatic Index 97.66

Aromaticity 0.0933

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 49975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207806 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus maritimus [Animal]

FamilyBPI

Tax ID29073

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence