Peptide Database

Peptide NameSLAY-screened peptide P1741

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H155N25O31S

DescriptionStandard

        PTYALICYSYRQATSPTATK
    

Molecular Weight2235.51 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.87

Charge Density (pH 7.0) 0.0972

GRAVY Index-0.36

Hydrophobic Moment 0.41

Boman Index0.01

Instability Index44.48

Aliphatic Index 54.00

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 906.52

LogP -10.37

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 66.0

Heavy Atoms 157.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335595 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/