Peptide Database

Peptide NameSLAY-screened peptide P495

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC67H124N20O19S3

DescriptionStandard

        TRSTLLCCRSILML
    

Molecular Weight1610.02 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)1.38

Net Charge (pH 7.4) 1.16

Charge Density (pH 7.0) 0.0985

GRAVY Index1.04

Hydrophobic Moment 0.48

Boman Index0.09

Instability Index85.81

Aliphatic Index 139.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 646.34

LogP -6.18

H-bond Donors 27.0

H-bond Acceptors 24.0

Rotatable Bonds 54.0

Heavy Atoms 109.0

Ring Count 0.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145404 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/