‹ ›
MYP_087705
← PREVIOUS NEXT → BACK
Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C201H296N50O63
Standard
Sequence
YTSLIHSLIEEGQNQQEKNEQELLELDKWASLWNWF
Physicochemical Analysis
4420.80 Da
4.30
-5.14
-5.41
-0.1427
-0.86
0.50
-0.03
51.95
89.44
0.1389
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1873.79
-14.32
62.0
59.0
149.0
314.0
9.0
42.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0153766 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1N43D/S138A:inhibition of virus replication in HeLa cells
0.185±0.068 μM
EC50
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0209228 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1V38A | HeLa cells
0.065±0.0088 μM
EC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. | Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M. | J Biol Chem. 2009 Feb 20;284(8):4914-20. | DOI:10.1074/jbc.M807169200 | PMID:19073606 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0279880 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1N43D:inhibition of virus replication in HeLa cells
0.141±0.026 μM
EC50
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0281232 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 N43D
PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
RECORD: Rec_0329903 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1N43D/S138A | HeLa cells
0.185±0.068 μM
EC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. | Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M. | J Biol Chem. 2009 Feb 20;284(8):4914-20. | DOI:10.1074/jbc.M807169200 | PMID:19073606 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/
FIRST PREV 1 2 3 NEXT LAST
Showing 5 records on this page · Page 2 of 3