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MYP_087673
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Basic Information
casoxin (fr.33-38 of bovine kappa-casein)
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Standard
6 amino acids
C35H49N9O11
Standard
Sequence
SRYPSY
Physicochemical Analysis
771.82 Da
8.31
0.46
0.25
0.0764
-1.72
0.44
-0.38
80.53
0.00
0.3333
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
342.85
-3.53
13.0
12.0
20.0
55.0
3.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014055 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casoxin
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Antagonist
opioid receptor
PaperXu R. J. Bioactive peptides in milk and their biological and health implications. Food. Rev. Int. 14(1), 1-16, 1998.
RECORD: Rec_0035731 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
shows opioid antagonist activity
15 μM
IC50
RECORD: Rec_0058128 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand Opioid antagonist
PaperContents of agonistic and antagonistic opioid peptides in different cheese varieties | Sienkiewicz-Szłapka, E. et al. | DOI: 10.1016/j.idairyj.2008.10.011 Evidence URLhttps://www.uniprot.org/uniprotkb/P02668/entry
RECORD: Rec_0128626 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
RECORD: Rec_0265948 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand Hypocholesterolemic Opioid antagonist
PaperCasomokinins, opioid/vaso-relaxing peptides derivatized from casoxin-d or β-casomorphin-6 | Yoshikawa, M. et al. | DOI: 10.1016/j.peptides.2015.07.013 Evidence URLhttps://www.uniprot.org/uniprotkb/P02668/entry