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MYP_087653
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Basic Information
Bacteriocin 97518
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
24 amino acids
C90H139N27O35S5
Standard
Sequence
ITSVSWCTPGCTSEGGGSGCSHCC
Physicochemical Analysis
2319.55 Da
5.24
-1.20
-1.53
-0.0500
0.16
0.21
0.21
55.06
28.33
0.0417
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
967.44
-17.78
40.0
40.0
69.0
157.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003579 VERIFIED: YES
Provenance & Taxonomy
Planomonospora sp. [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Moraxella catarrhalis
PaperPubMed PMID: 17469849 PMID17469849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17469849/
RECORD: Rec_0012902 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0028448 VERIFIED: YES
Provenance & Taxonomy
Planomonospora sp. [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
PaperPubMed PMID: 17469849 PMID17469849 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17469849/
RECORD: Rec_0084585 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0221005 VERIFIED: YES
Provenance & Taxonomy
Planomonospora alba [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
The primary structure, as well as the mode of intrabonds, of the peptide has been revised based on a combined analytical techniques (Maffioli SI et al 2009). The updated sequence before post translation is diaplayed. Chemical modification: Residues T2 and S5 are dehydrated. Lanthionines occur between S3-C7, S13-C20, S18-C23, and S21-C24. One methyllanthionine is proposed between T8 and C11. In addition, the carboxylic acids of E14 and the C-terminus are benzylamidated. The peptide is not active against E.coli and C.albicans, but is active against Gram-negative pathogenic bacterium M. catarrhalis (MIC 1 ug/ml). It inhibits cell wall synthesis of Gram-positive bacteria, including S. aureus MRSA. Structure: 3D structure has been determined by NMR (Vasile F et al., 2012). Updated 5/2014; 7/2021
Bio-Activity Profile
Antimicrobial
Gram-negative pathogenic bacterium M. catarrhalis
1 μg/mL
MIC
PaperA novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.
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