Peptide Database

Peptide NameSLAY-screened peptide P1566

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC101H153N31O30

DescriptionStandard

        HPKYLSRTTHGSISHQYPTA
    

Molecular Weight2281.49 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)2.02

Net Charge (pH 7.4) 1.66

Charge Density (pH 7.0) 0.1009

GRAVY Index-1.10

Hydrophobic Moment 0.45

Boman Index-0.12

Instability Index14.90

Aliphatic Index 44.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 977.53

LogP -12.06

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 68.0

Heavy Atoms 162.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0148023 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-Gram-negative Antibacterial Antimicrobial

TargetEscherichia coli

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/