Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length470 amino acids

Chemical FormulaC2308H3638N586O675S17

DescriptionStandard

        MSLWCVTVALLGLLTPALSTDPGVIVQLTQQGLEYGRQIGIASLQQKLNSIKIPDISGSEDVSPIGKVEYSLSQMHITNLGLPASSLGLVPGSGLSLSISDAFISLNGHWHVKYLKFIKDSGSFDLTVSGLTISVTMGVNSDETGRPTVSSSNCAASVGHVSIEFHGGASWLYNLFSSFIENALRSAIQNQICPLVHDAISDINPHLKTMNVLAQVDKYAEIEYSLVTSPVVSNTFIQFSLKGEFYKIGQHQEPPFSAPPFSLPQTNGSMLYLGLSSFIANSAGFVYHNAGVLGLYVTDDMIPSSSPLRLNTKTFGAFIPEIAKRFPNMMMKLLVKTLEPPRITFEPNNVTLQANGTVTAYAILPNNTLEALFILNLEASVSAELHVSGLNIAGSVTLNSDCGILMWHFQVMPLNNIFTMILKVVVIPKVNEKLQQGYPLPAISHMNLVNTQLKVLKDYILVGTDVHFTQ
    

Molecular Weight50940.20 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-6.37

Net Charge (pH 7.4) -7.39

Charge Density (pH 7.0) -0.0136

GRAVY Index0.25

Hydrophobic Moment 0.70

Boman Index0.22

Instability Index38.10

Aliphatic Index 106.36

Aromaticity 0.0809

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340143 VERIFIED: NO

Provenance & Taxonomy

OrganismScleropages formosus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence