Peptide Database

Peptide NameC8(FIV ectodomain 770-777)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC59H76N14O13

DescriptionStandard

        WEDWVRWI
    

Molecular Weight1189.32 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.1545

GRAVY Index-0.69

Hydrophobic Moment 0.83

Boman Index0.09

Instability Index93.81

Aliphatic Index 85.00

Aromaticity 0.3750

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 450.89

LogP 1.27

H-bond Donors 17.0

H-bond Acceptors 12.0

Rotatable Bonds 33.0

Heavy Atoms 86.0

Ring Count 6.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0348750 VERIFIED: YES

Provenance & Taxonomy

OrganismFeline immunodeficiency virus [Virus]

FamilyVirus-derived peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetFeline immunodeficiency virus (Replication); MBM

Activity0.050448 μM

MethodELISA

PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/

RECORD: Rec_0391262 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetFIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells

Activity0.07±0.02 μg/mL

MethodIC50

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