Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2373H3764N618O671S14

DescriptionStandard

        DKGEKMLKTWYLFLLCWLSLRLEANPGLKVRITQKGLDCGWRIGMELLKQAVLKETFPSWSGQESFSVVKVNYIISRLRINAVDFPETSASFISGTGIYLSVAQASATISADWRVHSWLLRDQGQITVSISGLFIAVIFKVSRDSTGHLSTLLHSCQLSIDSVKVKLSGGSSWIYSFPSGYLEKPIHTKLDKSLCLNIKNKIQMMDALLRKHKVLSQIDAFAQVDYSLVSSPEVFKSHINLDLKGTVYPAGNHTDPPFAPAPFALPNQGDSMIYLGVSNYFLKSASLAYYRAGAFNISISKELDSTFNLNDSLLRCFVSEIAQSYAAASAVLLRLMATSPPAVSLNADRCVLQITGCVEVVAVLPNSTTQYVFAGNLTASTRVNLTISKQKLIISLLLKRFQFSLLHSSLGFPDKSLVENFLSYALQRIVIPVINDKLGKGFPLLNLAHTSLTGSVIKINQGHLVICTDVHYQ
    

Molecular Weight52135.92 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)13.65

Net Charge (pH 7.4) 12.68

Charge Density (pH 7.0) 0.0289

GRAVY Index0.20

Hydrophobic Moment 0.66

Boman Index0.15

Instability Index30.60

Aliphatic Index 108.41

Aromaticity 0.0930

Extinction Coeff. Reduced 60850.00

Extinction Coeff. Oxidized 61350.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0122853 VERIFIED: NO

Provenance & Taxonomy

OrganismCorvus brachyrhynchos [Animal]

FamilyBPI/LBP

Tax ID85066

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria