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MYP_087514
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Basic Information
Spiderine OtTx1a
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
108 amino acids
C531H837N151O149S10
Standard
Sequence
KFKWGKLFSTAKKLYKKGKKLSKNKNFKKALKFGKQLAKNLQAGEEHEPGTPVGNNKCWAIGTTCSDDCDCCPEHHCHCPAGKWLPGLFRCTCQVTESDKVNKCPPAE
Physicochemical Analysis
12040.90 Da
9.29
11.02
10.42
0.1020
-0.82
0.72
-0.15
34.50
47.04
0.0833
17990.00
18615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4843.22
-50.25
172.0
174.0
406.0
841.0
23.0
116.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208935 VERIFIED: YES
Provenance & Taxonomy
Lynx spider [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23088912 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23088912/
RECORD: Rec_0233488 VERIFIED: YES
Provenance & Taxonomy
Oxyopes takobius [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
58-72; 65-77; 69-104; 71-93; 79-91
Bio-Activity Profile
Toxin Venom Antibacterial Host defense
PaperPDB 2N85 structural record; NMR; chain A; residues 1-41
RECORD: Rec_0242512 VERIFIED: YES
Provenance & Taxonomy
Oxyopes takobius [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis VKM B-501
0.12-0.25 μM
MIC
PMID24118933 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24118933/
RECORD: Rec_0263072 VERIFIED: YES
Provenance & Taxonomy
Oxyopes takobius [Animal]
Spiderine
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal
PaperFEBS J. 2013 Dec;280(23):6247-61 | http://www.ncbi.nlm.nih.gov/pubmed/24118933 PMID24118933 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24118933/
RECORD: Rec_0407262 VERIFIED: YES
Provenance & Taxonomy
Oxyopes takobius [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DH5
0.12-0.25 μM
MIC
PMID24118933 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24118933/
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