Peptide Database

Peptide NameDermaseptin-PT9 (DPT9) (DRS-PT9)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length71 amino acids

Chemical FormulaC353H571N91O111S5

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKRENEMEQEDDEQSEMKRGLWSKIKDAAKTAGKAALGFVNEMVGEQ
    

Molecular Weight8026.18 Da

Isoelectric Point (pI)4.78

Net Charge (pH 7.0)-4.48

Net Charge (pH 7.4) -4.75

Charge Density (pH 7.0) -0.0631

GRAVY Index-0.31

Hydrophobic Moment 0.65

Boman Index-0.03

Instability Index47.53

Aliphatic Index 85.21

Aromaticity 0.0704

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3307.10

LogP -28.24

H-bond Donors 113.0

H-bond Acceptors 112.0

Rotatable Bonds 288.0

Heavy Atoms 560.0

Ring Count 6.0

Amide Bonds 75.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0096981 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0115683 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Hemolytic

TargetEnterococcus faecalis (Gram-positive)

RECORD: Rec_0236811 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0258917 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Hemolytic

TargetK. pneumoniae (Gram-negative)

RECORD: Rec_0409449 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Hemolytic

TargetEscherichia coli (Gram-negative)

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