Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length527 amino acids

Chemical FormulaC2617H4115N707O731S15

DescriptionStandard

        GAGRECRAEAGMAARSLVAFSTVLAMCLALTRATNPGFVVRITQAGLDYAHQHGIAVLQKELAQLKLPDISGDFRVRHLGKVHYEISSLNLRDFHLPYSRISLVPNVGLQVAISNAFAEVDGNWRVKFHFIRDHGSFNLEVKNVYIKIDLKLGSDTSGKPTVSTSACSTRISSVHVHFSGKFGWLYNLFYSAVESRFRKILEGKVCDSVVSSVSGDLQRYLQTLPVTAKIDAKAGIDYSLVAPPVATAQTLDVDLKGEFFSMAHRGAVPFHPPVLAFPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDSMIPKDVEFHLNTSTFAAFIPQLDKMYPNMLMKLRLSAPSAPFLSIAPDGISLQPTVDIQAYAILPNSSLAPLFLLSLTGNVSATIDVKSGHIVGNLSVGRMKLSLKHSDVGTFKVRMLQSIMNIYASSILLPRVNGNNLLGGRGLLEQSPASPVLPTLVPTKPRALSFPERLAEGFPLPLPERIQLSNILVQFHQNFLLLGADVHYTPRERRS
    

Molecular Weight57658.94 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)11.32

Net Charge (pH 7.4) 10.05

Charge Density (pH 7.0) 0.0215

GRAVY Index0.12

Hydrophobic Moment 0.65

Boman Index0.13

Instability Index37.26

Aliphatic Index 99.18

Aromaticity 0.0911

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33600.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0202890 VERIFIED: NO

Provenance & Taxonomy

OrganismColinus virginianus [Animal]

FamilyBPI

Tax ID9014

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence