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MYP_087295
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Basic Information
Piscidin-2 (Pis-2; fish, chordates, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C122H187N35O25
Standard
Sequence
FFHHIFRGIVHVGKTIHKLVTG
Physicochemical Analysis
2544.01 Da
11.17
3.11
2.70
0.1412
0.48
0.73
0.28
15.02
110.45
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
943.54
-4.50
34.0
32.0
82.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0062026 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Neurospora crassa
1.56-3.12 μM
MIC
PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
RECORD: Rec_0062269 VERIFIED: YES
Provenance & Taxonomy
Hybrid striped bass [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
50 μM
MIC
PMID28122029 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28122029/
RECORD: Rec_0064331 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida lusitania
10-20 μM
MIC
PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
RECORD: Rec_0073488 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Piscidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0078775 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
1.252-5 μM
MIC
PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
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