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MYP_087295
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Basic Information
Piscidin-2 (Pis-2; fish, chordates, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
22 amino acids
C122H187N35O25
Standard
Sequence
FFHHIFRGIVHVGKTIHKLVTG
Physicochemical Analysis
2544.01 Da
11.17
3.11
2.70
0.1412
0.48
0.73
0.28
15.02
110.45
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
943.54
-4.50
34.0
32.0
82.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0030144 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Piscidin
46259
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-CCV Entry inhibition
Channel Catfish virus (CCV)
4 μM
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperInactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. | Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L. | Virology. 2004 Jun 1;323(2):268-75. | DOI:10.1016/j.virol.2004.02.029 | PMID:15193922 PMID15193922 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15193922/
RECORD: Rec_0039625 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Pleurocidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Streptococcus equisimilis
2.5-5 μM
MIC
PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
RECORD: Rec_0043753 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Neisseria gonorrhoeae
20 μM
MIC
PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
RECORD: Rec_0045721 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterococcus faecalis
5-10 μM
MIC
PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
RECORD: Rec_0050115 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Piscidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Sheep erythrocytes
20 μM
Hemolysis
PaperLauth X, Shike H, Burns JC, et al. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15;277(7):5030-5039. doi:10.1074/jbc.M109173200. PMID11739390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11739390/
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