Peptide Database

Peptide NameD4D20-S4

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiparasitic ▸ Antimalarial

Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC131H224N34O35

DescriptionStandard

        ALWDTLLKKVLKAAAKAALDAVLVGANA
    

Molecular Weight2835.39 Da

Isoelectric Point (pI)9.53

Net Charge (pH 7.0)1.79

Net Charge (pH 7.4) 1.60

Charge Density (pH 7.0) 0.0641

GRAVY Index0.84

Hydrophobic Moment 0.71

Boman Index0.28

Instability Index-2.43

Aliphatic Index 146.79

Aromaticity 0.0357

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1106.81

LogP -7.01

H-bond Donors 38.0

H-bond Acceptors 37.0

Rotatable Bonds 95.0

Heavy Atoms 200.0

Ring Count 2.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0384424 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HSV Entry inhibition

TargetHSV-2 acyclovir-resistant strain (ROI2) | Vero cells

Activity9.63 μM

MethodEC50

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperIn vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2. | Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K. | J Med Virol. 2013 Feb;85(2):272-81. | DOI:10.1002/jmv.23450 | PMID:23161023 PMID23161023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23161023/

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