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MYP_086993
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Basic Information
PB1 (381-386)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
6 amino acids
C31H48N10O12
Standard
Sequence
FNESTR
Physicochemical Analysis
752.77 Da
6.00
-0.24
-0.44
-0.0395
-1.70
0.72
-0.52
40.43
0.00
0.1667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
391.57
-5.56
14.0
12.0
24.0
53.0
1.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028924 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Influenza A virus(A/California/07/2009 (H1N1)pdm09/):antiviral activity of the peptide in MDCK cells
664±3 μM
ED50
PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. Antiviral Res. 2015 Jan;113:4-10. doi: 10.1016/j.antiviral.2014.10.015. PMID: 25446335. PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/
RECORD: Rec_0120856 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus(A/California/07/2009 (H1N1)pdm09/) | MDCK cells
664±3 μM
ED50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. | Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI. | Antiviral Res. 2015 Jan;113:4-10. | DOI:10.1016/j.antiviral.2014.10.015 | PMID:25446335 PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/
RECORD: Rec_0312798 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. Antiviral Res. 2015 Jan;113:4-10. doi: 10.1016/j.antiviral.2014.10.015. PMID: 25446335. PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/