Peptide Database

Peptide NameSLAY-screened peptide P2811

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC113H176N38O29S

DescriptionStandard

        TRFWQICTNSNLRTLRWNRP
    

Molecular Weight2562.91 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.39

Net Charge (pH 7.4) 3.18

Charge Density (pH 7.0) 0.1694

GRAVY Index-1.04

Hydrophobic Moment 0.43

Boman Index-0.35

Instability Index81.98

Aliphatic Index 58.50

Aromaticity 0.1500

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1139.89

LogP -12.05

H-bond Donors 43.0

H-bond Acceptors 34.0

Rotatable Bonds 80.0

Heavy Atoms 181.0

Ring Count 6.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0276332 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/