Peptide Database

Peptide NameMacromomycin (MCR) (Auromomycin apoprotein)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length144 amino acids

Chemical FormulaC601H969N171O201S5

DescriptionStandard

        MLQNTSRFLARAGATVGVAAGLAFSLPADRDGAPGVTVTPATGLSNGQTVTVSATGLTPGTVYHVGQCAVVEPGVIGCDATTSTDVTADAAGKITAQLKVHSSFQAVVGANGTPWGTVNCKVVSCSAGLGSDSGEGAAQAITFA
    

Molecular Weight13966.47 Da

Isoelectric Point (pI)5.42

Net Charge (pH 7.0)-2.36

Net Charge (pH 7.4) -2.75

Charge Density (pH 7.0) -0.0164

GRAVY Index0.33

Hydrophobic Moment 0.71

Boman Index0.23

Instability Index8.76

Aliphatic Index 82.01

Aromaticity 0.0417

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5844.99

LogP -83.17

H-bond Donors 206.0

H-bond Acceptors 206.0

Rotatable Bonds 441.0

Heavy Atoms 978.0

Ring Count 15.0

Amide Bonds 153.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0008477 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces macromomyceticus [Bacterium]

FamilyNeocarzinostatin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Cytotoxic Non-hemolytic