Peptide Database

Peptide NameSLAY-screened peptide P5240

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H163N31O28

DescriptionStandard

        THPHLYAYRTKYGSYGHLKV
    

Molecular Weight2391.68 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)2.65

Net Charge (pH 7.4) 2.30

Charge Density (pH 7.0) 0.1327

GRAVY Index-0.91

Hydrophobic Moment 0.23

Boman Index-0.05

Instability Index-5.54

Aliphatic Index 58.50

Aromaticity 0.2000

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 949.02

LogP -6.89

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 72.0

Heavy Atoms 171.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0181598 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/