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MYP_086855
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Basic Information
Misgurin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C106H189N41O29
Standard
Sequence
RQRVEELSKFSKKGAAARRRK
Physicochemical Analysis
2501.89 Da
11.84
6.76
6.55
0.3220
-1.64
0.61
-0.75
80.69
46.67
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1217.05
-14.46
46.0
36.0
93.0
176.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0189684 VERIFIED: YES
Provenance & Taxonomy
Oriental weatherfish [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Likely chlorinated. Synthetic peptide showed identical activity. Hence, chemical modification may be unimportant or does not occur (unless a modified aa is used)
Bio-Activity Profile
Antimicrobial Antifungal
more active than magainin 2
12-100 μg/mL
MIC
PaperA novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus.
RECORD: Rec_0215791 VERIFIED: YES
Provenance & Taxonomy
Oriental weatherfish [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Likely chlorinated. Synthetic peptide showed identical activity. Hence, chemical modification may be unimportant or does not occur (unless a modified aa is used)
Bio-Activity Profile
Antimicrobial Antifungal
Serratia sp
16 μg/mL
MIC
PaperA novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus.
RECORD: Rec_0224974 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://patents.google.com/patent/US20030096949A1/en PatentUS 2003/0096949 A1
RECORD: Rec_0243813 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Sheep erythrocytes
25 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/9271200/ PMID9271200 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9271200/
RECORD: Rec_0261290 VERIFIED: YES
Provenance & Taxonomy
Misgurnus anguillicaudatus [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium
PMID9271200 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9271200/
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