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MYP_086855
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Basic Information
Misgurin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C106H189N41O29
Standard
Sequence
RQRVEELSKFSKKGAAARRRK
Physicochemical Analysis
2501.89 Da
11.84
6.76
6.55
0.3220
-1.64
0.61
-0.75
80.69
46.67
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1217.05
-14.46
46.0
36.0
93.0
176.0
1.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0116212 VERIFIED: YES
Provenance & Taxonomy
Misgurnus anguillicaudatus [Animal]
75329
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
40 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0117956 VERIFIED: NO
Provenance & Taxonomy
Misgurnus anguillicaudatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Antifungal Fungicide Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
PMID9271200 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9271200/; https://www.uniprot.org/uniprotkb/P81474/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0120977 VERIFIED: YES
Provenance & Taxonomy
Misgurnus anguillicaudatus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas putida
PaperPubMed PMID: 9271200 PMID9271200 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9271200/
RECORD: Rec_0127634 VERIFIED: YES
Provenance & Taxonomy
Misgurnus anguillicaudatus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Cryptococcus neoformans
PaperPubMed PMID: 9271200 PMID9271200 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9271200/
RECORD: Rec_0130808 VERIFIED: YES
Provenance & Taxonomy
Misgurnus anguillicaudatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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