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MYP_086831
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Basic Information
PAF26
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
6 amino acids
C49H67N13O7
Standard
Sequence
RKKWFW
Physicochemical Analysis
950.14 Da
11.17
2.76
2.55
0.4597
-1.88
0.07
-0.45
8.33
0.00
0.5000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
354.34
1.03
14.0
10.0
29.0
69.0
5.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0395848 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Screened from [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation and C-terminal amidation
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli O29
20 μM
MIC
PaperIdentification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
RECORD: Rec_0402009 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
P. italicum PHI-1
22±3 μM
IC50
PMID11976121;28556271;28428776 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11976121/
RECORD: Rec_0402603 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Screened from [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation and C-terminal amidation
Bio-Activity Profile
Antimicrobial Antifungal
T. rubrum
20-30 μM
MIC
PaperIdentification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
RECORD: Rec_0408680 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0411023 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Screened from [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
N-terminal acetylation and C-terminal amidation
Bio-Activity Profile
Antimicrobial Antifungal
P. digitatum PHI-26
20 μM
MIC
PaperIdentification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library.
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