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MYP_086794
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Basic Information
NL16
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
8 amino acids
C43H82N16O9
Standard
Sequence
VPRRKAKI
Physicochemical Analysis
967.21 Da
12.00
3.73
3.52
0.4665
-0.99
0.54
-0.61
84.39
97.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
434.07
-3.20
16.0
13.0
33.0
68.0
1.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035489 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/
RECORD: Rec_0217571 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
1000 μM
IC50
PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/
RECORD: Rec_0241521 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
1000 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme. | Li HY, Zawahir Z, Song LD, Long YQ, Neamati N. | J Med Chem. 2006 Jul 27;49(15):4477-86. | DOI:10.1021/jm060307u | PMID:16854053 PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/
RECORD: Rec_0268029 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
1000 μM
IC50
PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/
RECORD: Rec_0301041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
1000 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme. | Li HY, Zawahir Z, Song LD, Long YQ, Neamati N. | J Med Chem. 2006 Jul 27;49(15):4477-86. | DOI:10.1021/jm060307u | PMID:16854053 PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/