Peptide Database

Peptide NameDefensin DEFB126

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length91 amino acids

Chemical FormulaC426H698N122O129S13

DescriptionStandard

        NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG
    

Molecular Weight10009.68 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)7.78

Net Charge (pH 7.4) 7.40

Charge Density (pH 7.0) 0.0854

GRAVY Index-0.33

Hydrophobic Moment 0.46

Boman Index-0.05

Instability Index44.49

Aliphatic Index 50.33

Aromaticity 0.0549

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4041.49

LogP -48.56

H-bond Donors 149.0

H-bond Acceptors 151.0

Rotatable Bonds 325.0

Heavy Atoms 690.0

Ring Count 14.0

Amide Bonds 96.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0048503 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsAPD analysis reveals that the sequence of the peptide shows 45% similarity to hBD-26 Mol Wt: 10009.806; GRAVY: -0.326. Different from classic human beta defensins, this peptide contains one additional long C-terminal tail for glycosylation that confers negative charge to the surface of the sperm, essential for its maturation and effective transport in the female reproductive tract (Tollner et al., 2011). Deletion mutants are unable to increase sperm motility (Aram et al., 2020). For a review, please refer to Tollner et al., 2012)

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-inflammatory